2-Amino-5-fluoro-6-methylpyridine

Name: 2-Amino-5-fluoro-6-methylpyridine
Brand: ChemScene
Availability: InStock
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CAS No. 110919-71-6
Cat. No. CS-W021568
Purity≥97%
MDL No.MFCD09835298

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Amino-5-fluoro-6-methylpyridine|CS-W021568

Structure of 110919-71-6

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General Information

CAS No. 110919-71-6
Cat. No. CS-W021568
Purity ≥97%
MDL No. MFCD09835298
Storage RT, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₇FN₂
Molecular Weight None
Synonym(s) 5-Fluoro-6-Methylpyridin-2-aMine
SMILES NC1=NC(=C(C=C1)F)C

Description

2-Amino-5-fluoro-6-methylpyridine features a pyridine core functionalized with amino, fluoro, and methyl groups at positions 2, 5, and 6, respectively. This electron-deficient heterocycle integrates readily into pharmaceutical scaffolds, offering enhanced metabolic stability and tunable solubility under standard conditions.

Application

2-Amino-5-fluoro-6-methylpyridine serves as a versatile building block in medicinal chemistry, enabling efficient access to functionalized pyridine scaffolds. Its amino and fluorine substituents offer orthogonal reactivity for late-stage diversification, while the methyl group enhances metabolic stability. The compound exhibits excellent bench stability and compatibility with standard coupling reactions, facilitating streamlined synthesis of bioactive heterocycles.

Synthesis

Route1
- 110919-70-5
- ~82%
- In-stock
  
  110919-71-6
References
- Sanchez; Rogowski Journal of Heterocyclic Chemistry, 1987 , vol. 24, # 1 p. 215 - 217
Route2
- 5671-67-0
- ~%
- In-stock
  
  110919-71-6
References
- Journal of Heterocyclic Chemistry, , vol. 24, # 1 p. 215 - 217

Safety Information

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GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

Quality Control

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Computational Chemistry Data

TPSA 38.91
LogP 1.11132
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Amino-5-fluoro-6-methylpyridine

CAS No. 110919-71-6

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