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CS-W001157 4
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2-Methyl-6-nitropyridine

  • CAS No. 18368-61-1

  • Cat. No. CS-0044032
  • Purity≥95%
  • MDL No.MFCD04114203

*For research and further manufacturing use only, not for direct human use.

2-Methyl-6-nitropyridine|CS-0044032

Structure of 18368-61-1

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General Information

  • CAS No. 18368-61-1
  • Cat. No. CS-0044032
  • Purity ≥95%
  • MDL No. MFCD04114203
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆N₂O₂
  • Molecular Weight 138.12
  • Synonym(s) Pyridine, 2-methyl-6-nitro- (9CI)
  • SMILES O=[N+](C1=CC=CC(C)=N1)[O-]

Description

2-Methyl-6-nitropyridine features a nitro group at the para position relative to the methyl substituent, imparting strong electron-withdrawing character. This electronic profile enhances reactivity in nucleophilic substitution and metal-catalyzed coupling processes. The molecule exhibits bench-stable handling under standard conditions, enabling straightforward integration into synthetic workflows requiring nitrogen-rich heterocyclic scaffolds.

Application

2-Methyl-6-nitropyridine serves as a versatile building block in heterocyclic synthesis, enabling direct functionalization at the pyridine ring due to the electron-withdrawing nitro group and directing effect of the methyl substituent. Its stability under standard reaction conditions facilitates nucleophilic substitution, metal-catalyzed coupling, and reduction protocols, making it valuable for constructing complex pharmaceutical intermediates and agrochemical scaffolds.

Synthesis

  • Route1

    References

    • Krohn, Karsten; Kuepke, Jochen; Rieger, Hagen Advanced Synthesis and Catalysis, 1997 , vol. 339, # 4 p. 335 - 339

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   56.03
  • LogP   1.29822
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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