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CS-W001157 4
Total: USD 88.00

dBET1

  • CAS No. 1799711-21-9

  • Cat. No. CS-0021961
  • Purity≥98%
  • MDL No.MFCD31544503

*For research and further manufacturing use only, not for direct human use.

dBET1|CS-0021961

Structure of 1799711-21-9

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General Information

  • CAS No. 1799711-21-9
  • Cat. No. CS-0021961
  • Purity ≥98%
  • MDL No. MFCD31544503
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₈H₃₇ClN₈O₇S
  • Molecular Weight 785.27
  • Synonym(s) None
  • SMILES O=C(NCCCCNC(COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)=O)C[C@H]4C5=NN=C(C)N5C6=C(C(C)=C(C)S6)C(C7=CC=C(Cl)C=C7)=N4

Description

dBET1 is a potent, selective degrader targeting BRD4, designed to induce ubiquitin-mediated proteolysis of the bromodomain protein. This molecule features a bifunctional architecture linking a BRD4-binding warhead to an E3 ligase recruiter, enabling efficient and targeted degradation under physiological conditions.

Application

dBET1 serves as a potent, cell-permeable degrader of BRD4, enabling targeted protein degradation via the ubiquitin-proteasome system. Its structure incorporates a thalidomide-derived ligand for CRBN recruitment and a selective BRD4-binding moiety, facilitating efficient ternary complex formation. The compound exhibits high stability in physiological conditions and enables robust, dose-dependent degradation of BRD4 in cellular assays, making it a valuable tool for studying BET protein function and validating therapeutic target engagement in epigenetic research.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   194.05
  • LogP   3.68246
  • H_Acceptors   12
  • H_Donors   3
  • Rotatable_Bonds   12

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