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CS-W001157 4
Total: USD 88.00

ARV-771

  • CAS No. 1949837-12-0

  • Cat. No. CS-6389
  • Purity≥98%
  • MDL No.MFCD30738017

*For research and further manufacturing use only, not for direct human use.

ARV-771|CS-6389

Structure of 1949837-12-0

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General Information

  • CAS No. 1949837-12-0
  • Cat. No. CS-6389
  • Purity ≥98%
  • MDL No. MFCD30738017
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄₉H₆₀ClN₉O₇S₂
  • Molecular Weight 986.64
  • Synonym(s) None
  • SMILES CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@H](C4=NN=C(N42)C)CC(NCCOCCCOCC(N[C@H](C(N5C[C@@H](C[C@H]5C(N[C@@H](C)C6=CC=C(C=C6)C7=C(C)N=CS7)=O)O)=O)C(C)(C)C)=O)=O

Description

ARV-771 is a potent, cell-permeable inhibitor targeting the E3 ubiquitin ligase complex. This compound features a unique scaffold that enables selective engagement with target proteins, facilitating their degradation via the ubiquitin-proteasome pathway. Designed for robust in vivo stability and favorable pharmacokinetics, ARV-771 supports precision targeting in oncology research.

Application

ARV-771 serves as a versatile building block for constructing biologically relevant heterocyclic scaffolds, enabling efficient access to medicinally active compounds through well-established coupling and cyclization protocols. Its bench-stable nature and tolerance to diverse functional groups facilitate straightforward purification and integration into complex molecular architectures common in drug discovery campaigns.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   202.26
  • LogP   6.53118
  • H_Acceptors   14
  • H_Donors   4
  • Rotatable_Bonds   18

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