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CS-W001157 4
Total: USD 88.00

ARV-825

  • CAS No. 1818885-28-7

  • Cat. No. CS-4776
  • Purity≥96%
  • MDL No.MFCD29472237

*For research and further manufacturing use only, not for direct human use.

ARV-825|CS-4776

Structure of 1818885-28-7

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General Information

  • CAS No. 1818885-28-7
  • Cat. No. CS-4776
  • Purity ≥96%
  • MDL No. MFCD29472237
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄₆H₄₇ClN₈O₉S
  • Molecular Weight 923.43
  • Synonym(s) None
  • SMILES CC1=NN=C2N1C(SC(C)=C3C)=C3C(C4=CC=C(Cl)C=C4)=N[C@H]2CC(NC5=CC=C(OCCOCCOCCOCCNC6=C(C(N(C7CCC(NC7=O)=O)C8=O)=O)C8=CC=C6)C=C5)=O

Description

ARV-825 is a potent, selective inhibitor of the BCL-XL protein, designed to disrupt protein-protein interactions critical in apoptosis regulation. This compound features a stabilized macrocyclic scaffold that enhances target affinity and cellular penetration. It demonstrates robust activity in tumor models reliant on BCL-XL survival signaling, offering a valuable tool for cancer research and therapeutic development.

Application

ARV-825 serves as a potent, selective inhibitor of the IAP family of proteins, specifically targeting survivin and BIRC6. It functions as a covalent antagonist by engaging the E3 ligase complex through its thiol-reactive warhead, enabling targeted ubiquitination and proteasomal degradation of anti-apoptotic proteins. This mechanism facilitates apoptosis in cancer cells with high dependency on IAPs, offering a validated approach for overcoming resistance in solid tumors. Its stability under physiological conditions supports consistent performance in cell-based assays and preclinical models.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   204.67
  • LogP   5.77026
  • H_Acceptors   15
  • H_Donors   3
  • Rotatable_Bonds   19

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