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CS-W001157 4
Total: USD 88.00

dBET6

  • CAS No. 1950634-92-0

  • Cat. No. CS-0047679
  • Purity≥98%
  • MDL No.MFCD31692407

*For research and further manufacturing use only, not for direct human use.

dBET6|CS-0047679

Structure of 1950634-92-0

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General Information

  • CAS No. 1950634-92-0
  • Cat. No. CS-0047679
  • Purity ≥98%
  • MDL No. MFCD31692407
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄₂H₄₅ClN₈O₇S
  • Molecular Weight 841.37
  • Synonym(s) None
  • SMILES O=C(NCCCCCCCCNC(COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)=O)C[C@H]4C5=NN=C(C)N5C6=C(C(C)=C(C)S6)C(C7=CC=C(Cl)C=C7)=N4

Description

dBET6 is a potent, selective degrader of BRD4 that integrates into the ubiquitin-proteasome system via a thalidomide-based E3 ligase recruiter. This bifunctional molecule features a high-affinity bromodomain inhibitor moiety paired with a stable linker, enabling efficient target protein degradation under physiological conditions.

Application

dBET6 serves as a potent, cell-permeable degrader of BRD4, enabling targeted protein degradation via the ubiquitin-proteasome system. It functions as a bifunctional molecule linking a BRD4-binding domain to an E3 ligase recruiter, facilitating selective ubiquitination and subsequent degradation of the target protein. Its design supports robust activity in cellular assays and provides a validated tool for probing BET protein function in epigenetic research.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   194.05
  • LogP   5.24286
  • H_Acceptors   12
  • H_Donors   3
  • Rotatable_Bonds   16

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