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CS-W001157 4
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2-Amino-6-methoxypyridine

  • CAS No. 17920-35-3

  • Cat. No. CS-W003213
  • Purity≥98%
  • MDL No.MFCD04972542

*For research and further manufacturing use only, not for direct human use.

2-Amino-6-methoxypyridine|CS-W003213

Structure of 17920-35-3

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General Information

  • CAS No. 17920-35-3
  • Cat. No. CS-W003213
  • Purity ≥98%
  • MDL No. MFCD04972542
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈N₂O
  • Molecular Weight None
  • Synonym(s) 6-METHOXY-PYRIDIN-2-YLAMINE
  • SMILES NC1=NC(OC)=CC=C1

Description

2-Amino-6-methoxypyridine is a bench-stable heterocyclic building block featuring an electron-rich pyridine core. The amino and methoxy groups enable direct functionalization at adjacent positions, facilitating coupling reactions under mild conditions. This compound integrates readily into pharmaceutical intermediates and agrochemical scaffolds due to its solubility in polar organic solvents and compatibility with diverse reaction environments.

Application

2-Amino-6-methoxypyridine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based scaffolds through Suzuki-Miyaura and Buchwald-Hartwig coupling reactions. Its ortho-amino and meta-methoxy substituents provide complementary reactivity for sequential functionalization, while the compound exhibits good bench stability and ease of purification—ideal for iterative synthesis workflows in API development.

Synthesis

  • Route1

    References

    • Chemical Communications, , vol. 46, # 6 p. 925 - 927
  • Route2

    References

    • Organic Letters, , vol. 15, # 14 p. 3734 - 3737
  • Route3

    References

    • Journal of the American Chemical Society, , vol. 69, p. 1147,1148

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   0.6724
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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