Lot numbers can be found on the outside label of a product:
4,5-Dichloro-2-methylpyridazin-3(2H)-one
-
CAS No. 933-76-6
- Cat. No. CS-W022047
- Purity≥97%
- MDL No.MFCD00051686
*For research and further manufacturing use only, not for direct human use.
Structure of 933-76-6
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 933-76-6
- Cat. No. CS-W022047
- Purity ≥97%
- MDL No. MFCD00051686
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₅H₄Cl₂N₂O
- Molecular Weight 179.00
- Synonym(s) 5-24-02-00023 (Beilstein Handbook Reference)
- SMILES O=C1C(Cl)=C(Cl)C=NN1C
Description
4,5-Dichloro-2-methylpyridazin-3(2H)-one is a bench-stable heterocyclic scaffold featuring two chlorine substituents at the 4 and 5 positions and a methyl group at C2. This electron-deficient core integrates readily into medicinal chemistry campaigns, offering enhanced metabolic stability and strategic reactivity for coupling reactions in drug discovery workflows.
Application
4,5-Dichloro-2-methylpyridazin-3(2H)-one serves as a versatile building block in medicinal chemistry, enabling the construction of heterocyclic scaffolds through nucleophilic substitution and coupling reactions. Its dichloro substitution pattern facilitates selective functionalization at C4 or C5, while the methyl and carbonyl groups offer orthogonal reactivity for downstream derivatization. The compound exhibits bench stability and compatibility with standard purification methods, making it well-suited for scalable synthesis and API development workflows.
Synthesis
-
Route1
-
In-stock
932-22-9 -
74-88-4 - ~74%
-
In-stock
933-76-6
References
-
CEPHALON, INC. Patent: WO2009/142732 A2, 2009 ; Location in patent: Page/Page column 61-62 ; WO 2009/142732 A2
-
-
Route2
-
87-56-9
-
60-34-4
- ~90%
-
In-stock
933-76-6
References
-
Hergenrother, Paul J.; Putt, Karson S.; Liu, Xianjun Patent: US2007/32496 A1, 2007 ; Location in patent: Page/Page column 13 ;
-
-
Route3
-
608-42-4
-
60-34-4
- ~74%
-
In-stock
933-76-6
References
-
Chen, Shih-Fong; Panzica, Raymond P. Journal of Organic Chemistry, 1981 , vol. 46, # 12 p. 2467 - 2473
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS06
|
|
Signal Word : Danger
|
UN#: 2811
|
|
Class : 6.1
|
Packing Group : Ⅲ
|
|
Hazard Statements : H301-H315-H317-H319-H335
|
|
|
Precautionary Statements : P261-P264-P270-P271-P272-P280-P302+P352-P304+P340-P330-P362-P405-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 34.89
- LogP 1.0871
- H_Acceptors 3
- H_Donors 0
- Rotatable_Bonds 0
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- 4,5-Dichloro-2-methylpyridazin-3(2H)-one sigma4,5-Dichloro-2-methylpyridazin-3(2H)-one manufacturer4,5-Dichloro-2-methylpyridazin-3(2H)-one price4,5-Dichloro-2-methylpyridazin-3(2H)-one structure4,5-Dichloro-2-methylpyridazin-3(2H)-one SDSbuy 4,5-Dichloro-2-methylpyridazin-3(2H)-one4,5-Dichloro-2-methylpyridazin-3(2H)-one supplier4,5-Dichloro-2-methylpyridazin-3(2H)-one uses4,5-Dichloro-2-methylpyridazin-3(2H)-one molecular weightprice of 4,5-Dichloro-2-methylpyridazin-3(2H)-one4,5-Dichloro-2-methylpyridazin-3(2H)-one chemical name formula of 4,5-Dichloro-2-methylpyridazin-3(2H)-one