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CS-W001157 4
Total: USD 88.00

4-Bromo-6-methoxypyridin-2-amine

  • CAS No. 1211526-95-2

  • Cat. No. CS-0146018
  • Purity≥97%
  • MDL No.MFCD18258916

*For research and further manufacturing use only, not for direct human use.

4-Bromo-6-methoxypyridin-2-amine|CS-0146018

Structure of 1211526-95-2

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General Information

  • CAS No. 1211526-95-2
  • Cat. No. CS-0146018
  • Purity ≥97%
  • MDL No. MFCD18258916
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇BrN₂O
  • Molecular Weight 203.04
  • Synonym(s) None
  • SMILES NC1=NC(OC)=CC(Br)=C1

Description

4-Bromo-6-methoxypyridin-2-amine features a pyridine core with strategically positioned bromo and methoxy groups, enabling selective coupling in cross-coupling reactions. The electron-rich amine facilitates efficient functionalization, while the ortho-bromo substitution enhances reactivity under palladium catalysis. This bench-stable intermediate integrates readily into complex heterocyclic scaffolds for medicinal chemistry applications.

Application

4-Bromo-6-methoxypyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyridine-based scaffolds through palladium-catalyzed cross-coupling reactions. The bromo group facilitates reliable Suzuki, Buchwald–Hartwig, and Negishi couplings, while the ortho-amino and methoxy functionalities provide complementary sites for further derivatization. Its bench-stable nature and straightforward purification support scalable synthesis and integration into complex molecular architectures.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   1.4349
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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