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CS-W001157 4
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4-Chloro-6-methoxypyridin-2-amine

  • CAS No. 1261628-71-0

  • Cat. No. CS-0197723
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Chloro-6-methoxypyridin-2-amine|CS-0197723

Structure of 1261628-71-0

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General Information

  • CAS No. 1261628-71-0
  • Cat. No. CS-0197723
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇ClN₂O
  • Molecular Weight 158.59
  • Synonym(s) 4-Chloro-6-methoxy-2-pyridinamine
  • SMILES ClC=1C=C(N=C(N)C1)OC

Description

4-Chloro-6-methoxypyridin-2-amine features a pyridine core functionalized with chlorine and methoxy groups, enabling selective coupling in medicinal chemistry. The ortho-chloro substituent facilitates palladium-catalyzed cross-coupling reactions, while the amino group serves as a direct handle for derivatization. This scaffold demonstrates stability under standard reaction conditions and compatibility with diverse synthetic transformations.

Application

4-Chloro-6-methoxypyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyridine-based scaffolds. The chloro group facilitates palladium-catalyzed cross-coupling reactions, while the methoxy and amino functionalities offer orthogonal handles for further derivatization. Its bench-stable nature and compatibility with standard reaction conditions make it well-suited for modular synthesis workflows in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   1.3258
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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