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Structure of 17880-61-4
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Methyl 5-ethynylpicolinate is a synthetically valuable pyridine derivative featuring a terminal alkyne group at the 5-position. This functionality enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation and click chemistry applications. The ester moiety offers compatibility with nucleophilic transformations, while the electron-deficient pyridine ring enhances reactivity in cross-coupling processes.
Methyl 5-ethynylpicolinate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to functionalized heterocycles via copper-catalyzed azide-alkyne cycloaddition (CuAAC) and other alkyne-directed transformations. Its terminal alkyne group exhibits excellent stability under standard reaction conditions and facilitates straightforward purification. The ester functionality supports further derivatization, including hydrolysis and coupling reactions, making it valuable for constructing bioactive scaffolds and advanced intermediates in medicinal chemistry and materials science.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: