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CS-W001157 4
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Methyl 5-bromo-6-fluoropicolinate

  • CAS No. 1214336-44-3

  • Cat. No. CS-0312388
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Methyl 5-bromo-6-fluoropicolinate|CS-0312388

Structure of 1214336-44-3

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General Information

  • CAS No. 1214336-44-3
  • Cat. No. CS-0312388
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BrFNO₂
  • Molecular Weight 234.02
  • Synonym(s) methyl 5-bromo-6-fluoro-pyridine-2-carboxylate
  • SMILES O=C(C1=NC(F)=C(Br)C=C1)OC

Description

Methyl 5-bromo-6-fluoropicolinate is a fluorinated heterocyclic ester featuring complementary halogen substituents at the 5 and 6 positions of the picolinate core. This electron-deficient scaffold enables selective cross-coupling reactions under palladium catalysis, offering high functional group tolerance. The methyl ester facilitates downstream derivatization while maintaining stability under standard bench conditions.

Application

Methyl 5-bromo-6-fluoropicolinate serves as a versatile building block for heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The bromo and fluoro substituents provide complementary sites for sequential functionalization, while the methyl ester facilitates downstream transformations. This compound exhibits excellent bench stability and is compatible with standard reaction conditions in medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   1.7698
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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