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7-(Difluoromethyl)-1,2,3,4-Tetrahydroquinoline

  • CAS No. 1783624-20-3

  • Cat. No. CS-0142919
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

7-(Difluoromethyl)-1,2,3,4-Tetrahydroquinoline|CS-0142919

Structure of 1783624-20-3

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General Information

  • CAS No. 1783624-20-3
  • Cat. No. CS-0142919
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₁F₂N
  • Molecular Weight 183.20
  • Synonym(s) 7-(Difluoromethyl)-1,2,3,4-Tetrahydroquinoline(WXC01614)
  • SMILES FC(C1=CC2=C(C=C1)CCCN2)F

Description

7-(Difluoromethyl)-1,2,3,4-tetrahydroquinoline is a fluorinated heterocyclic scaffold featuring a difluoromethyl group at the 7-position, enhancing metabolic stability and modulating electronic properties. This bench-stable compound integrates readily into medicinal chemistry campaigns targeting CNS agents and kinase inhibitors, offering improved lipophilicity and bioavailability over non-fluorinated analogs.

Application

7-(Difluoromethyl)-1,2,3,4-tetrahydroquinoline serves as a valuable building block in medicinal chemistry, enabling direct incorporation of a difluoromethyl group at the quinoline C7 position. The difluoromethyl moiety offers enhanced metabolic stability and modulated lipophilicity, while the tetrahydroquinoline core provides a rigid, bioactive scaffold suitable for target-directed synthesis. Its bench-stable nature and compatibility with standard coupling reactions facilitate efficient derivatization in multi-step syntheses.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   2.9823
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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