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CS-W001157 4
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2-Chloropyrimidine-5-carbaldehyde

  • CAS No. 933702-55-7

  • Cat. No. CS-0019369
  • Purity≥98%
  • MDL No.MFCD10696891

*For research and further manufacturing use only, not for direct human use.

2-Chloropyrimidine-5-carbaldehyde|CS-0019369

Structure of 933702-55-7

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General Information

  • CAS No. 933702-55-7
  • Cat. No. CS-0019369
  • Purity ≥98%
  • MDL No. MFCD10696891
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClN₂O
  • Molecular Weight 142.54
  • Synonym(s) 2-ChloropyriMidine-5-carboxyaldehyde
  • SMILES O=CC1=CN=C(Cl)N=C1

Description

2-Chloropyrimidine-5-carbaldehyde features a reactive aldehyde group flanked by a chlorine-substituted pyrimidine ring, enabling direct coupling in heterocyclic synthesis. This bench-stable electrophile integrates efficiently into medicinal chemistry scaffolds and serves as a key intermediate for bioactive compound development.

Application

2-Chloropyrimidine-5-carbaldehyde serves as a versatile building block in medicinal chemistry and heterocyclic synthesis. Its dual reactive functionalities—electrophilic chloro group and aldehyde moiety—enable sequential functionalization via nucleophilic substitution and carbonyl addition reactions. The compound exhibits good bench stability, facilitates straightforward purification, and supports efficient coupling with amines, thiols, and enolizable systems, making it well-suited for constructing complex pyrimidine-based scaffolds in API development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   42.85
  • LogP   0.9425
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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