2,4-Difluoro-5-Methoxybenzaldehyde

Name: 2,4-Difluoro-5-Methoxybenzaldehyde
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 177034-25-2
Cat. No. CS-0134629
Purity≥98%
MDL No.MFCD24539280

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2,4-Difluoro-5-Methoxybenzaldehyde|CS-0134629

Structure of 177034-25-2

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General Information

CAS No. 177034-25-2
Cat. No. CS-0134629
Purity ≥98%
MDL No. MFCD24539280
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₆F₂O₂
Molecular Weight 172.13
Synonym(s) None
SMILES O=CC1=CC(OC)=C(F)C=C1F

Description

2,4-Difluoro-5-methoxybenzaldehyde features a strategically positioned aldehyde group flanked by two fluorine atoms and a methoxy substituent, delivering enhanced electron-withdrawing character and improved metabolic stability. This combination enables efficient incorporation into pharmaceutical intermediates and functional materials under standard conditions.

Application

2,4-Difluoro-5-methoxybenzaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of heterocyclic scaffolds via electrophilic substitution and coupling reactions. Its strategic fluorine and methoxy substituents enhance metabolic stability and modulate electronic properties, while the aldehyde functionality facilitates facile derivatization through reductive amination, Wittig reactions, and condensation protocols. Bench-stable and readily purified by crystallization, it functions reliably in multi-step syntheses requiring functional group tolerance and predictable reactivity.

Synthesis

Route1
- 4885-02-3
- In-stock
  
  452-10-8
- ~78%
- In-stock
  
  177034-25-2
References
- BRISTOL-MYERS SQUIBB COMPANY Patent: WO2006/76246 A2, 2006 ; Location in patent: Page/Page column 171-172 ; WO 2006/076246 A2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

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Computational Chemistry Data

TPSA 26.3
LogP 1.7859
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Aldehyde

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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2,4-Difluoro-5-Methoxybenzaldehyde

CAS No. 177034-25-2

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