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CS-W001157 4
Total: USD 88.00

2-Fluoro-3-methoxybenzaldehyde

  • CAS No. 103438-88-6

  • Cat. No. CS-0089681
  • Purity≥98%
  • MDL No.MFCD03411962

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-3-methoxybenzaldehyde|CS-0089681

Structure of 103438-88-6

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General Information

  • CAS No. 103438-88-6
  • Cat. No. CS-0089681
  • Purity ≥98%
  • MDL No. MFCD03411962
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇FO₂
  • Molecular Weight 154.14
  • Synonym(s) 2-Fluoro-3-formylanisole
  • SMILES O=CC1=CC=CC(OC)=C1F

Description

2-Fluoro-3-methoxybenzaldehyde delivers a strategically positioned fluorine and methoxy group on the aromatic ring, enabling enhanced metabolic stability and modulated electronic properties. This electron-rich aldehyde integrates efficiently into coupling reactions and serves as a key building block in medicinal chemistry and agrochemical synthesis.

Application

2-Fluoro-3-methoxybenzaldehyde serves as a valuable building block in medicinal chemistry, enabling the synthesis of fluorinated heterocycles and bioactive scaffolds. Its ortho-fluoro and meta-methoxy substituents provide enhanced metabolic stability and modulate electronic properties. The aldehyde functionality facilitates direct incorporation into imines, hydrazones, and Ugi-type reactions, offering efficient access to diverse compound libraries with favorable bench stability and straightforward purification.

Synthesis

  • Route1
    • null|null
      693220-47-2
    • ~85%
    • In-stock
      2-Fluoro-3-methoxybenzaldehyde|CS-0089681
      103438-88-6

    References

    • ELI LILLY AND COMPANY Patent: WO2004/43931 A1, 2004 ; Location in patent: Page 40-41 ; WO 2004/043931 A1
  • Route2
    • In-stock
      1-Fluoro-2-methoxybenzene|CS-W011162
      321-28-8
    • null|null
      68-12-2
    • ~69%
    • In-stock
      2-Fluoro-3-methoxybenzaldehyde|CS-0089681
      103438-88-6

    References

    • SCHERING AKTIENGESELLSCHAFT Patent: WO2005/34939 A1, 2005 ; Location in patent: Page/Page column 67 ;
  • Route3

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 14 p. 4599 - 4604

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H317-H318-H335
Precautionary Statements : P261-P264-P270-P271-P272-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   1.6468
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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