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CS-W001157 4
Total: USD 88.00

N-(2-Hydroxyethyl)-N-methylacetamide

  • CAS No. 15567-95-0

  • Cat. No. CS-0112257
  • Purity≥95%
  • MDL No.MFCD10048086

*For research and further manufacturing use only, not for direct human use.

N-(2-Hydroxyethyl)-N-methylacetamide|CS-0112257

Structure of 15567-95-0

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General Information

  • CAS No. 15567-95-0
  • Cat. No. CS-0112257
  • Purity ≥95%
  • MDL No. MFCD10048086
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₁NO₂
  • Molecular Weight 117.15
  • Synonym(s) 2-(N-acetyl-N-methyl)aminoethanol
  • SMILES CC(N(CCO)C)=O

Description

N-(2-Hydroxyethyl)-N-methylacetamide is a polar, bench-stable amide featuring a hydroxyl group and a methylated nitrogen, enabling solubility in aqueous and organic media. This dual-functional structure facilitates use in bioconjugation, solvent systems, and as a building block for functionalized polymers and pharmaceutical intermediates.

Application

N-(2-Hydroxyethyl)-N-methylacetamide serves as a versatile bifunctional building block, enabling efficient conjugation of hydrophilic and lipophilic moieties in synthetic workflows. The amide functionality provides stability and compatibility with standard reaction conditions, while the pendant hydroxyl group facilitates further derivatization or solubility enhancement in polar media. This compound demonstrates excellent bench stability and ease of purification, making it well-suited for use in peptide modifications, drug delivery systems, and the construction of bioactive heterocyclic scaffolds.

Synthesis

  • Route1
    • In-stock
      2-(Methylamino)ethanol|CS-W008875
      109-83-1
    • null|null
      108-24-7
    • ~96%
    • In-stock
      N-(2-Hydroxyethyl)-N-methylacetamide|CS-0112257
      15567-95-0

    References

    • Yadav, Veejendra K.; Babu, K. Ganesh Journal of Organic Chemistry, 2004 , vol. 69, # 2 p. 577 - 580
  • Route2
    • 2-(Methylamino)ethyl acetate hydrochloride|CS-0452701
      4527-98-4
    • ~%
    • In-stock
      N-(2-Hydroxyethyl)-N-methylacetamide|CS-0112257
      15567-95-0

    References

    • Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft, , vol. 300, # 2 p. 148 - 156
  • Route3
    • In-stock
      Azido-PEG1|CS-0148425
      1517-05-1
    • null|null
      67-64-1
    • ~%
    • In-stock
      N-(2-Hydroxyethyl)-N-methylacetamide|CS-0112257
      15567-95-0

    References

    • Journal of Organic Chemistry, , vol. 64, # 12 p. 4381 - 4385

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   40.54
  • LogP   -0.543
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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