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CS-W001157 4
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N-Acetyl-N-methylglycine

  • CAS No. 5888-91-5

  • Cat. No. CS-0169319
  • Purity≥97%
  • MDL No.MFCD00021748

*For research and further manufacturing use only, not for direct human use.

N-Acetyl-N-methylglycine|CS-0169319

Structure of 5888-91-5

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General Information

  • CAS No. 5888-91-5
  • Cat. No. CS-0169319
  • Purity ≥97%
  • MDL No. MFCD00021748
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₉NO₃
  • Molecular Weight 131.13
  • Synonym(s) N-Acetyl-N-Methyl-glycine
  • SMILES O=C(O)CN(C(C)=O)C

Description

N-Acetyl-N-methylglycine offers a compact, stable scaffold for peptide derivatization, combining a masked amine with a hydrolytically robust acetyl group. This bifunctional motif enables site-specific conjugation in synthetic biology workflows, while its solubility and low aggregation propensity support efficient coupling under standard conditions.

Application

N-Acetyl-N-methylglycine serves as a stable, bench-ready building block for peptide and heterocyclic synthesis. Its acetylated amine and methylated alpha-carbon provide enhanced metabolic stability and orthogonal reactivity, enabling efficient incorporation into bioactive scaffolds. The molecule facilitates selective derivatization and purification due to its balanced polarity and resistance to racemization.

Synthesis

  • Route1
    • tert-Butyl N-acetyl-N-methylglycinate|CS-1674709
      168553-60-4
    • ~95%
    • In-stock
      N-Acetyl-N-methylglycine|CS-0169319
      5888-91-5

    References

    • Saha, Uttam K.; Roy, Rene Tetrahedron Letters, 1995 , vol. 36, # 21 p. 3635 - 3638
  • Route2
    • In-stock
      N-Methylacetamide|CS-0031873
      79-16-3
    • null|null
      50-00-0
    • null|null
      201230-82-2
    • ~70%
    • In-stock
      N-Acetyl-N-methylglycine|CS-0169319
      5888-91-5

    References

    • Lin, J.J.; Knifton, John F. Journal of Organometallic Chemistry, 1991 , vol. 417, # 1/2 p. 99 - 110
  • Route3
    • N,N-Dimethylpyridin-4-amine Vonoprazan Impurity|CS-0167023
      1122-58-3
    • In-stock
      Sarcosine|CS-W018511
      107-97-1
    • null|null
      75-36-5
    • ~%
    • In-stock
      N-Acetyl-N-methylglycine|CS-0169319
      5888-91-5

    References

    • Abbott Laboratories Patent: US5110904 A1, 1992 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   57.61
  • LogP   -0.4507
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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