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CS-W001157 4
Total: USD 88.00

4-Amino-3-chlorophenol

  • CAS No. 17609-80-2

  • Cat. No. CS-W019864
  • Purity≥97%
  • MDL No.MFCD00801116

*For research and further manufacturing use only, not for direct human use.

4-Amino-3-chlorophenol|CS-W019864

Structure of 17609-80-2

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General Information

  • CAS No. 17609-80-2
  • Cat. No. CS-W019864
  • Purity ≥97%
  • MDL No. MFCD00801116
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆ClNO
  • Molecular Weight 143.57
  • Synonym(s) 3-13-00-01184 (Beilstein Handbook Reference)
  • SMILES OC1=CC(Cl)=C(N)C=C1

Description

4-Amino-3-chlorophenol features a para-amino group flanked by a meta-chloro substituent on the phenolic ring, delivering enhanced reactivity in nucleophilic substitution and coupling reactions. This electron-rich scaffold enables efficient integration into pharmaceutical intermediates and functional materials under standard conditions.

Application

4-Amino-3-chlorophenol serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct access to substituted anilines and heterocyclic scaffolds. Its ortho-chloro and amino groups provide complementary reactivity for palladium-catalyzed cross-couplings, electrophilic substitutions, and amide formation. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis workflows.

Synthesis

  • Route1
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      4-Amino-3-chlorophenol|CS-W019864
      17609-80-2
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      95-51-2

    References

    • US2198249 , ;
  • Route2

    References

    • DE143449 ;
  • Route3
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      88-73-3
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    • In-stock
      4-Amino-3-chlorophenol|CS-W019864
      17609-80-2

    References

    • US2446519 , ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   1.6278
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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