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4-Chloro-7-methoxyquinoline-6-carboxamide

  • CAS No. 417721-36-9

  • Cat. No. CS-0014253
  • Purity≥97%
  • MDL No.MFCD13192256

*For research and further manufacturing use only, not for direct human use.

4-Chloro-7-methoxyquinoline-6-carboxamide|CS-0014253

Structure of 417721-36-9

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General Information

  • CAS No. 417721-36-9
  • Cat. No. CS-0014253
  • Purity ≥97%
  • MDL No. MFCD13192256
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₉ClN₂O₂
  • Molecular Weight 236.65
  • Synonym(s) synthesis-024
  • SMILES O=C(C1=C(OC)C=C2N=CC=C(Cl)C2=C1)N

Description

4-Chloro-7-methoxyquinoline-6-carboxamide features a quinoline core with strategically positioned electron-withdrawing and donor groups, enabling robust conjugation in synthetic transformations. The chloro and methoxy substituents enhance reactivity and solubility, while the carboxamide moiety provides a versatile handle for derivatization. This compound serves as a key scaffold in medicinal chemistry and materials science applications.

Application

4-Chloro-7-methoxyquinoline-6-carboxamide serves as a versatile building block in medicinal chemistry, enabling efficient access to quinoline-based scaffolds through palladium-catalyzed cross-coupling reactions. Its chloro group facilitates C–C and C–N bond formation under standard conditions, while the methoxy and carboxamide functionalities offer orthogonal reactivity and enhanced solubility. The compound exhibits excellent bench stability and ease of purification, making it well-suited for high-throughput synthesis and process development workflows.

Synthesis

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      417721-35-8
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    • In-stock
      4-Chloro-7-methoxyquinoline-6-carboxamide|CS-0014253
      417721-36-9

    References

    • Arimoto, Itaru; Yoshizawa, Kazuhiro; Kamada, Atsushi Patent: US2007/117842 A1, 2007 ; Location in patent: Page/Page column 6 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   65.21
  • LogP   1.9957
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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