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CS-W001157 4
Total: USD 88.00

6-Aminoquinazolin-4(3H)-one

  • CAS No. 17329-31-6

  • Cat. No. CS-W005348
  • Purity≥98%
  • MDL No.MFCD01219542

*For research and further manufacturing use only, not for direct human use.

6-Aminoquinazolin-4(3H)-one|CS-W005348

Structure of 17329-31-6

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General Information

  • CAS No. 17329-31-6
  • Cat. No. CS-W005348
  • Purity ≥98%
  • MDL No. MFCD01219542
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇N₃O
  • Molecular Weight 161.16
  • Synonym(s) ASINEX-REAG BAS 10150436
  • SMILES O=C1NC=NC2=C1C=C(N)C=C2

Description

6-Aminoquinazolin-4(3H)-one is a bench-stable, electron-rich heterocycle featuring a strategically positioned amino group that enhances solubility and reactivity. This core structure integrates readily into medicinal chemistry campaigns, serving as a key scaffold for kinase inhibitors and bioactive molecule development.

Application

6-Aminoquinazolin-4(3H)-one serves as a versatile scaffold in medicinal chemistry, enabling rapid access to bioactive heterocycles through straightforward functionalization at the amino and carbonyl positions. Its bench-stable nature and compatibility with standard coupling reactions facilitate efficient synthesis of quinazoline-based candidates for kinase inhibition and other target classes.

Synthesis

  • Route1

    References

    • BRISTOL-MYERS SQUIBB COMPANY Patent: WO2008/79836 A2, 2008 ; Location in patent: Page/Page column 86 ; WO 2008/079836 A2
  • Route2

    References

    • Tetrahedron Letters, , vol. 44, # 24 p. 4455 - 4458

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   71.77
  • LogP   0.5053
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   0

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