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CS-W001157 4
Total: USD 88.00

3-N-Boc-3-(Methylamino)piperidine

  • CAS No. 172478-01-2

  • Cat. No. CS-W019802
  • Purity≥97%
  • MDL No.MFCD06656642

*For research and further manufacturing use only, not for direct human use.

3-N-Boc-3-(Methylamino)piperidine|CS-W019802

Structure of 172478-01-2

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General Information

  • CAS No. 172478-01-2
  • Cat. No. CS-W019802
  • Purity ≥97%
  • MDL No. MFCD06656642
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₂N₂O₂
  • Molecular Weight 214.30
  • Synonym(s) tert-Butyl Methyl(piperidin-3-yl)carbamate
  • SMILES O=C(OC(C)(C)C)N(C)C1CNCCC1

Description

3-N-Boc-3-(methylamino)piperidine is a protected piperidine derivative featuring a methylamino group and a Boc-masked nitrogen, enabling straightforward deprotection and functionalization. This scaffold integrates readily into medicinal chemistry libraries, offering enhanced solubility and stability during synthesis.

Application

3-N-Boc-3-(methylamino)piperidine serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted piperidine scaffolds. The Boc group provides stable protection of the nitrogen, facilitating sequential functionalization and purification under standard conditions. It reacts predictably with electrophiles and participates reliably in reductive amination and coupling protocols, making it well-suited for modular synthesis of bioactive molecules.

Synthesis

  • Route1
    • null|null
      1279817-03-6
    • ~%
    • In-stock
      3-N-Boc-3-(Methylamino)piperidine|CS-W019802
      172478-01-2

    References

    • US2005/159423 A1, ; Page/Page column 18 ;
  • Route2
    • Benzyl 3-(tert-butoxycarbonylamino)piperidine-1-carboxylate|CS-W001566
      406213-47-6
    • null|null
      74-88-4
    • ~%
    • In-stock
      3-N-Boc-3-(Methylamino)piperidine|CS-W019802
      172478-01-2

    References

    • EP1568699 A1, ; Page/Page column 42 ;
  • Route3
    • null|null
      172477-99-5
    • ~92%
    • In-stock
      3-N-Boc-3-(Methylamino)piperidine|CS-W019802
      172478-01-2

    References

    • Barlocco, Daniela; Villa, Stefania; Fratta, Walter; Fadda, Paola; Colombo, Diego; Toma, Lucio Tetrahedron, 1995 , vol. 51, # 42 p. 11547 - 11556

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   41.57
  • LogP   1.6053
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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