(R)-1-Boc-2-Hydroxymethyl-piperazine

Name: (R)-1-Boc-2-Hydroxymethyl-piperazine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 169448-87-7
Cat. No. CS-D0658
Purity≥95%
MDL No.MFCD07772092

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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(R)-1-Boc-2-Hydroxymethyl-piperazine|CS-D0658

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General Information

CAS No. 169448-87-7
Cat. No. CS-D0658
Purity ≥95%
MDL No. MFCD07772092
Storage RT, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₂₀N₂O₃
Molecular Weight 216.28
Synonym(s) tert-butyl (2R)-2-(hydroxymethyl)piperazine-1-carboxylate
SMILES O=C(OC(C)(C)C)N1[C@@H](CO)CNCC1

Description

(R)-1-Boc-2-Hydroxymethyl-piperazine features a chiral piperazine core with a stable Boc-protected amine and a pendant hydroxymethyl group, enabling selective derivatization. This bench-stable scaffold integrates readily into complex molecular architectures, offering enhanced solubility and functional handle versatility in medicinal chemistry workflows.

Application

(R)-1-Boc-2-hydroxymethylpiperazine serves as a versatile chiral building block for the synthesis of bioactive molecules, enabling efficient access to piperazine-based scaffolds. The Boc group provides stable protection of the primary amine, while the pendant hydroxymethyl functionality allows for further derivatization via oxidation or coupling reactions. Its bench-stable nature and compatibility with standard peptide and heterocyclic coupling protocols make it well-suited for medicinal chemistry and process development workflows.

Synthesis

Route1
- In-stock
  
  252990-05-9
- ~97%
- In-stock
  
  169448-87-7
References
- ASTRAZENECA AB; ASTRAZENECA UK LIMITED Patent: WO2005/26152 A1, 2005 ; Location in patent: Page/Page column 136 ; WO 2005/026152 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 61.8
LogP 0.1876
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Alcohol

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

Key Words

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(R)-1-Boc-2-Hydroxymethyl-piperazine

CAS No. 169448-87-7

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