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CS-W001157 4
Total: USD 88.00

(S)-1-Boc-2-Hydroxymethyl-piperazine

  • CAS No. 1030377-21-9

  • Cat. No. CS-D0657
  • Purity≥95%
  • MDL No.MFCD07772093

*For research and further manufacturing use only, not for direct human use.

(S)-1-Boc-2-Hydroxymethyl-piperazine|CS-D0657

Structure of 1030377-21-9

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General Information

  • CAS No. 1030377-21-9
  • Cat. No. CS-D0657
  • Purity ≥95%
  • MDL No. MFCD07772093
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₂₀N₂O₃
  • Molecular Weight 216.28
  • Synonym(s) (s)-2-(hydroxymethyl)piperazine-1-carboxylic acid tert-butyl ester
  • SMILES O=C(OC(C)(C)C)N1[C@H](CO)CNCC1

Description

(S)-1-Boc-2-Hydroxymethyl-piperazine features a chiral piperazine core with a Boc-protected amine and a hydroxymethyl group, enabling selective functionalization in asymmetric synthesis. The pendant hydroxyl group offers versatility for derivatization, while the Boc handle ensures stability during multi-step transformations. This scaffold integrates readily into bioactive molecule design, particularly in kinase inhibitor and peptide mimic development.

Application

(S)-1-Boc-2-Hydroxymethyl-piperazine serves as a versatile chiral building block in medicinal chemistry, enabling the synthesis of piperazine-based scaffolds with defined stereochemistry. The Boc group provides stable protection of the primary amine, while the hydroxymethyl functionality offers a handle for further derivatization via oxidation, substitution, or coupling reactions. Its bench-stable nature and compatibility with standard peptide and heterocyclic synthesis protocols make it well-suited for iterative library construction and API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   61.8
  • LogP   0.1876
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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