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(R)-Piperazin-2-ylmethanol dihydrochloride

  • CAS No. 1217482-26-2

  • Cat. No. CS-0042552
  • Molecule weight189.08
  • Purity≥97%
  • MDL No.MFCD09954306

*For research and further manufacturing use only, not for direct human use.

(R)-Piperazin-2-ylmethanol dihydrochloride|CS-0042552

Structure of 1217482-26-2

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General Information

  • CAS No. 1217482-26-2
  • Cat. No. CS-0042552
  • Purity ≥97%
  • MDL No. MFCD09954306
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₄Cl₂N₂O
  • Molecular Weight 189.08
  • Synonym(s) (R)-piperazin-2-ylmethanol as 2HCl salt
  • SMILES OC[C@@H]1NCCNC1.[H]Cl.[H]Cl

Description

(R)-Piperazin-2-ylmethanol dihydrochloride is a bench-stable, moisture-tolerant chiral building block featuring a primary alcohol and a protonated piperazine nitrogen. This configuration enables direct incorporation into medicinal chemistry scaffolds, where the hydroxymethyl group facilitates further functionalization through etherification or oxidation. The dihydrochloride salt enhances solubility in polar solvents and supports efficient coupling reactions under standard conditions.

Application

(R)-Piperazin-2-ylmethanol dihydrochloride serves as a versatile chiral building block in medicinal chemistry, enabling efficient access to piperazine-containing scaffolds. Its well-defined stereochemistry and dual amine functionality facilitate selective derivatization, while the dihydrochloride salt form enhances bench stability and solubility for standard solution-phase syntheses.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   44.29
  • LogP   -0.6163
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   1

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