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CS-W001157 4
Total: USD 88.00

4-(2-Boc-aminoethyl)piperidine

  • CAS No. 165528-81-4

  • Cat. No. CS-B0446
  • Purity≥95%
  • MDL No.MFCD01318373

*For research and further manufacturing use only, not for direct human use.

4-(2-Boc-aminoethyl)piperidine|CS-B0446

Structure of 165528-81-4

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General Information

  • CAS No. 165528-81-4
  • Cat. No. CS-B0446
  • Purity ≥95%
  • MDL No. MFCD01318373
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₄N₂O₂
  • Molecular Weight 228.34
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)NCCC1CCNCC1

Description

4-(2-Boc-aminoethyl)piperidine features a protected amine handle ideal for late-stage functionalization in peptide and small-molecule synthesis. The Boc group ensures stability during handling and purification, while the piperidine core provides a rigid, basic scaffold suitable for bioactive molecule development under standard conditions.

Application

4-(2-Boc-aminoethyl)piperidine serves as a versatile building block in medicinal chemistry, enabling the construction of piperidine-based scaffolds through standard amine functionalization and deprotection protocols. The Boc group provides excellent bench stability and orthogonal handling during multi-step synthesis, facilitating efficient purification and compatibility with common coupling reactions. Its defined spatial orientation supports consistent stereochemical outcomes in target-directed synthesis.

Synthesis

  • Route1
    • Tert-butyl n-[2-(pyridin-4-yl)ethyl]carbamate|CS-0229984
      109573-05-9
    • ~95%
    • In-stock
      4-(2-Boc-aminoethyl)piperidine|CS-B0446
      165528-81-4

    References

    • GLAXO GROUP LIMITED Patent: WO2004/87145 A2, 2004 ; Location in patent: Page/Page column 31 ;
  • Route2

    References

    • Journal of Medicinal Chemistry, , vol. 49, # 14 p. 4116 - 4126
  • Route3
    • null|null
      100-43-6
    • ~%
    • In-stock
      4-(2-Boc-aminoethyl)piperidine|CS-B0446
      165528-81-4

    References

    • Journal of Medicinal Chemistry, , vol. 49, # 14 p. 4116 - 4126

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.36
  • LogP   1.9008
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   3

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