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tert-Butyl 4-(2-hydroxyethoxy)piperidine-1-carboxylate

  • CAS No. 163210-40-0

  • Cat. No. CS-0254693
  • Purity≥97%
  • MDL No.MFCD21092243

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-(2-hydroxyethoxy)piperidine-1-carboxylate|CS-0254693

Structure of 163210-40-0

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General Information

  • CAS No. 163210-40-0
  • Cat. No. CS-0254693
  • Purity ≥97%
  • MDL No. MFCD21092243
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₃NO₄
  • Molecular Weight 245.32
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)N1CCC(OCCO)CC1

Description

tert-Butyl 4-(2-hydroxyethoxy)piperidine-1-carboxylate features a piperidine core functionalized with a hydroxyethoxy side chain and a tert-butyl carbamate protecting group. This bifunctional scaffold enables direct incorporation into complex molecular architectures, offering orthogonal reactivity for late-stage derivatization in medicinal chemistry campaigns. The pendant hydroxyl group supports further modification via esterification or glycosylation, while the stable tert-butoxycarbonyl moiety facilitates purification and handling under standard bench conditions.

Application

tert-Butyl 4-(2-hydroxyethoxy)piperidine-1-carboxylate serves as a versatile piperidine-based building block, enabling efficient access to bioactive heterocycles through orthogonal functionalization. The pendant hydroxyethyl group facilitates downstream derivatization via etherification or esterification, while the tert-butyl carbamate provides robust protection under standard reaction conditions. Its bench-stable nature and compatibility with diverse coupling protocols make it well-suited for medicinal chemistry campaigns requiring flexible piperidine scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   59
  • LogP   1.3948
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   3

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