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CS-W001157 4
Total: USD 88.00

1-Boc-2-Methylpiperazine

  • CAS No. 120737-78-2

  • Cat. No. CS-W008720
  • Purity≥98%
  • MDL No.MFCD02179168

*For research and further manufacturing use only, not for direct human use.

1-Boc-2-Methylpiperazine|CS-W008720

Structure of 120737-78-2

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General Information

  • CAS No. 120737-78-2
  • Cat. No. CS-W008720
  • Purity ≥98%
  • MDL No. MFCD02179168
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₂₀N₂O₂
  • Molecular Weight 200.28
  • Synonym(s) Tert-Butyl-2-Methyl-1-Piperazinecarboxylate
  • SMILES O=C(OC(C)(C)C)N1C(C)CNCC1

Description

1-Boc-2-Methylpiperazine delivers a protected piperazine scaffold with enhanced stability and solubility in organic media. The tert-butoxycarbonyl group enables straightforward deprotection under mild acidic conditions, facilitating integration into complex molecular architectures. This bench-stable derivative simplifies handling during synthetic workflows involving nitrogen heterocycles.

Application

1-Boc-2-methylpiperazine serves as a versatile nitrogen source in medicinal chemistry, enabling efficient construction of piperazine-based scaffolds. The Boc group provides excellent stability and ease of removal under mild acidic conditions, while the methyl substitution enhances solubility and modulates basicity. It functions reliably in amide coupling, reductive amination, and nucleophilic displacement reactions, offering predictable reactivity and straightforward purification—ideal for iterative synthesis and lead optimization workflows.

Synthesis

  • Route1
    • Tert-butyl 4-benzyl-2-methylpiperazine-1-carboxylate|CS-0324801
      120737-77-1
    • ~88%
    • In-stock
      1-Boc-2-Methylpiperazine|CS-W008720
      120737-78-2

    References

    • WO2007/135427 A1, ; Page/Page column 31 ; WO 2007/135427 A1
  • Route2
    • 4-Benzyl 1-(tert-butyl) 2-methylpiperazine-1,4-dicarboxylate|CS-0137101
      128102-16-9
    • ~96%
    • In-stock
      1-Boc-2-Methylpiperazine|CS-W008720
      120737-78-2

    References

    • US2010/35883 A1, ; Page/Page column 86 ;
  • Route3

    References

    • WO2011/130661 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   41.57
  • LogP   1.2152
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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