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CS-W001157 4
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5-Fluoro-4-methyl-2-nitropyridine

  • CAS No. 1628184-28-0

  • Cat. No. CS-0160708
  • Purity≥96%
  • MDL No.MFCD28798172

*For research and further manufacturing use only, not for direct human use.

5-Fluoro-4-methyl-2-nitropyridine|CS-0160708

Structure of 1628184-28-0

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General Information

  • CAS No. 1628184-28-0
  • Cat. No. CS-0160708
  • Purity ≥96%
  • MDL No. MFCD28798172
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅FN₂O₂
  • Molecular Weight None
  • Synonym(s) None
  • SMILES O=[N+](C1=NC=C(F)C(C)=C1)[O-]

Description

5-Fluoro-4-methyl-2-nitropyridine features a trifunctional pyridine core with electron-withdrawing nitro and fluoro groups paired with an activating methyl substituent. This combination enables selective C–H functionalization and facilitates coupling reactions in medicinal chemistry, particularly for constructing bioactive heterocycles under mild conditions.

Application

5-Fluoro-4-methyl-2-nitropyridine serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via nucleophilic aromatic substitution. The electron-deficient pyridine ring facilitates regioselective displacement of the fluorine atom, while the nitro and methyl groups offer orthogonal handles for further derivatization. Its bench-stable crystalline form simplifies handling and purification, making it well-suited for modular synthesis of heterocyclic scaffolds and API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   56.03
  • LogP   1.43732
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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