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CS-W001157 4
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3-Phenylmorpholine

  • CAS No. 138713-44-7

  • Cat. No. CS-0030635
  • Purity≥97%
  • MDL No.MFCD09608120

*For research and further manufacturing use only, not for direct human use.

3-Phenylmorpholine|CS-0030635

Structure of 138713-44-7

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General Information

  • CAS No. 138713-44-7
  • Cat. No. CS-0030635
  • Purity ≥97%
  • MDL No. MFCD09608120
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₃NO
  • Molecular Weight 163.22
  • Synonym(s) None
  • SMILES C1(C2=CC=CC=C2)NCCOC1

Description

3-Phenylmorpholine is a versatile heterocyclic compound featuring a morpholine ring substituted at the 3-position with a phenyl group. This structural motif imparts enhanced lipophilicity and electron-rich character, enabling integration into bioactive molecules. The compound exhibits bench-stable handling properties and serves as a key scaffold in medicinal chemistry for designing CNS-targeted therapeutics and functional materials.

Application

3-Phenylmorpholine serves as a versatile heterocyclic building block in medicinal chemistry, enabling the construction of diverse pharmacophores through standard coupling and functionalization protocols. Its stability under routine reaction conditions and tolerance to a range of functional groups facilitate efficient synthesis of complex molecules. The compound functions as a key scaffold for bioactive compounds, particularly in CNS-targeted drug discovery.

Synthesis

  • Route1

    References

    • Alexander, Rikki; Balasundaram, Ahrani; Batchelor, Mark; Brookings, Daniel; Crepy, Karen; Crabbe, Tom; Deltent, Marie-France; Driessens, Frank; Gill, Andrew; Harris, Sue; Hutchinson, Gillian; Kulisa, Claire; Merriman, Mark; Mistry, Prakash; Parton, Ted; Turner, James; Whitcombe, Ian; Wright, Sara Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 15 p. 4316 - 4320
  • Route2
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      1436416-04-4
    • ~0%
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      1436416-05-5
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      1436416-06-6
    • In-stock
      3-Phenylmorpholine|CS-0030635
      138713-44-7

    References

    • Sammons, Matthew; Jennings, Sandra M.; Herr, Michael; Hulford, Catherine A.; Wei, Liuqing; Hallissey, James F.; Kiser, E. Jason; Wright, Stephen W.; Piotrowski, David W. Organic Process Research and Development, 2013 , vol. 17, # 6 p. 934 - 939
  • Route3
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      74572-00-2
    • ~%
    • In-stock
      3-Phenylmorpholine|CS-0030635
      138713-44-7

    References

    • Bettoni, Giancarlo; Franchini, Carlo; Perrone, Roberto; Tortorella, Vincenzo Tetrahedron, 1980 , vol. 36, p. 409 - 415

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   1.3475
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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