1,4-Difluoro-2-iodobenzene

Name: 1,4-Difluoro-2-iodobenzene
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 2265-92-1
Cat. No. CS-0157075
Purity≥98%
MDL No.MFCD03094151

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 2265-92-1

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 2265-92-1
Cat. No. CS-0157075
Purity ≥98%
MDL No. MFCD03094151
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₃F₂I
Molecular Weight 239.99
Synonym(s) NSC 10262
SMILES C1=CC(=C(C=C1F)I)F

Description

1,4-Difluoro-2-iodobenzene features a strategically positioned iodine atom flanked by two fluorine substituents, enabling selective cross-coupling reactions. The electron-withdrawing fluorines enhance reactivity in palladium-catalyzed processes while maintaining stability under standard conditions. This aryl iodide serves as a key intermediate for constructing complex fluorinated scaffolds in medicinal chemistry and materials science.

Application

1,4-Difluoro-2-iodobenzene serves as a versatile building block in cross-coupling chemistry, enabling the construction of biaryl scaffolds under palladium-catalyzed conditions. The ortho-iodo and para-difluoro substituents provide orthogonal reactivity for sequential functionalization, while the molecule exhibits excellent bench stability and compatibility with standard reaction protocols. Its defined substitution pattern facilitates predictable coupling outcomes, making it ideal for the synthesis of fluorinated aromatic intermediates in medicinal chemistry and materials science applications.

Synthesis

Route1
- 540-36-3
- ~86%
- In-stock
  
  2265-92-1
References
- Prakash, G. K. Surya; Mathew, Thomas; Hoole, Dushyanthi; Esteves, Pierre M.; Wang, Qi; Rasul, Golam; Olah, George A. Journal of the American Chemical Society, 2004 , vol. 126, # 48 p. 15770 - 15776
Route2
- In-stock
  
  367-30-6
- ~%
- In-stock
  
  2265-92-1
References
- US2085736 , ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 0
LogP 2.5694
H_Acceptors 0
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

1,4-Difluoro-2-iodobenzene sigma1,4-Difluoro-2-iodobenzene manufacturer1,4-Difluoro-2-iodobenzene price1,4-Difluoro-2-iodobenzene structure1,4-Difluoro-2-iodobenzene SDSbuy 1,4-Difluoro-2-iodobenzene1,4-Difluoro-2-iodobenzene supplier1,4-Difluoro-2-iodobenzene uses1,4-Difluoro-2-iodobenzene molecular weightprice of 1,4-Difluoro-2-iodobenzene1,4-Difluoro-2-iodobenzene chemical name formula of 1,4-Difluoro-2-iodobenzene

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

1,4-Difluoro-2-iodobenzene

CAS No. 2265-92-1

Recommended Products