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Ethyl 2-acetoxy-2-(diethoxyphosphoryl)acetate

  • CAS No. 162246-77-7

  • Cat. No. CS-0139650
  • Purity≥97%
  • MDL No.MFCD04039534

*For research and further manufacturing use only, not for direct human use.

Ethyl 2-acetoxy-2-(diethoxyphosphoryl)acetate|CS-0139650

Structure of 162246-77-7

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General Information

  • CAS No. 162246-77-7
  • Cat. No. CS-0139650
  • Purity ≥97%
  • MDL No. MFCD04039534
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₉O₇P
  • Molecular Weight 282.23
  • Synonym(s) Ethyl2-Acetoxy-2-(diethoxyphosporyl)acetate
  • SMILES O=C(OCC)C(OC(C)=O)P(OCC)(OCC)=O

Description

Ethyl 2-acetoxy-2-(diethoxyphosphoryl)acetate features a reactive acetoxy group and a phosphonate moiety, enabling direct C–C bond formation via Horner-Wadsworth-Emmons reactions. This bench-stable reagent integrates seamlessly into synthetic sequences requiring phosphonate-based olefination, offering high functional group tolerance and predictable stereocontrol under mild conditions.

Synthesis

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      Ethyl 2-acetoxy-2-(diethoxyphosphoryl)acetate|CS-0139650
      162246-77-7

    References

    • US2012/157383 A1, ; Page/Page column 45 ; US 20120157383 A1
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      Ethyl 2-acetoxy-2-(diethoxyphosphoryl)acetate|CS-0139650
      162246-77-7

    References

    • HUGHES, Adam D.; FENSTER, Erik; FLEURY, Melissa; GENDRON, Roland Patent: US2013/109639 A1, 2013 ; Location in patent: Paragraph 0289-0290 ;
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      Ethyl 2-acetoxy-2-(diethoxyphosphoryl)acetate|CS-0139650
      162246-77-7

    References

    • Schmidt; Langner; Kirschbaum; Braun Synthesis, 1994 , # 11 p. 1138 - 1140

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS08
Signal Word : Danger
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H317-H319-H334-H335
Precautionary Statements : P260-P261-P264-P270-P271-P272-P280-P285-P302+P352-P304+P341-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P342+P311-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   88.13
  • LogP   1.7048
  • H_Acceptors   7
  • H_Donors   0
  • Rotatable_Bonds   8

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