Lot numbers can be found on the outside label of a product:
tert-Butyl 4-(6-aminopyridin-3-yl)piperidine-1-carboxylate
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CAS No. 1198408-35-3
- Cat. No. CS-0112822
- Purity≥95%
- MDL No.MFCD11111266
*For research and further manufacturing use only, not for direct human use.
Structure of 1198408-35-3
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General Information
- CAS No. 1198408-35-3
- Cat. No. CS-0112822
- Purity ≥95%
- MDL No. MFCD11111266
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₅H₂₃N₃O₂
- Molecular Weight 277.36
- Synonym(s) None
- SMILES O=C(N1CCC(C2=CC=C(N)N=C2)CC1)OC(C)(C)C
Description
tert-Butyl 4-(6-aminopyridin-3-yl)piperidine-1-carboxylate features a pyridine nitrogen positioned ortho to the piperidine tether, enabling direct functionalization. The tert-butyl carbamate group provides stability and ease of removal under mild acidic conditions. This scaffold integrates readily into medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds.
Application
tert-Butyl 4-(6-aminopyridin-3-yl)piperidine-1-carboxylate serves as a versatile building block for constructing pyridine-containing heterocycles in medicinal chemistry. The tert-butyl carbamate group provides excellent bench stability and ease of removal under mild acidic conditions, while the primary amine enables direct derivatization via acylation, alkylation, or coupling reactions. Its piperidine scaffold offers favorable conformational properties and functional group tolerance, facilitating integration into diverse API candidates through standard synthetic protocols.
Synthesis
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Route1
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![Tert-butyl 6-nitro-3',6'-dihydro-[3,4'-bipyridine]-1'(2'H)-carboxylate|CS-0492917](https://file.chemscene.com/productPIC/CS-0492917.gif)
1231930-22-5 - ~99%
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In-stock
1198408-35-3
References
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F. HOFFMANN-LA ROCHE AG; BROTHERTON-PLEISS, Christine; JAIME-FIGUEROA, Saul; LOPEZ-TAPIA, Francisco Javier; LOU, Yan; OWENS, Timothy D. Patent: WO2013/24078 A1, 2013 ; Location in patent: Page/Page column 57; 58 ;
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Route2
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![Tert-butyl 6-amino-3',6'-dihydro-[3,4'-bipyridine]-1'(2'H)-carboxylate|CS-0492918](https://file.chemscene.com/productPIC/CS-0492918.gif)
1279030-84-0 - ~58%
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In-stock
1198408-35-3
References
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Cho, Young Shin; Borland, Maria; Brain, Christopher; Chen, Christine H.-T.; Cheng, Hong; Chopra, Rajiv; Chung, Kristy; Groarke, James; He, Guo; Hou, Ying; Kim, Sunkyu; Kovats, Steven; Lu, Yipin; O'Reilly, Marc; Shen, Junqing; Smith, Troy; Trakshel, Gary; Voegtle, Markus; Xu, Mei; Xu, Ming; Sung, Moo Je Journal of Medicinal Chemistry, 2010 , vol. 53, # 22 p. 7938 - 7957
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Route3
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In-stock
375853-82-0 - ~%
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In-stock
1198408-35-3
References
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F. HOFFMANN-LA ROCHE AG; BROTHERTON-PLEISS, Christine; JAIME-FIGUEROA, Saul; LOPEZ-TAPIA, Francisco Javier; LOU, Yan; OWENS, Timothy D. Patent: WO2013/24078 A1, 2013 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 68.45
- LogP 2.7783
- H_Acceptors 4
- H_Donors 1
- Rotatable_Bonds 1
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Key Words
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