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CS-W001157 4
Total: USD 88.00

N-(3-Aminopropyl)-N-methylcarbamic acid tert-butyl ester

  • CAS No. 150349-36-3

  • Cat. No. CS-B0431
  • Purity≥97%
  • MDL No.MFCD01631189

*For research and further manufacturing use only, not for direct human use.

N-(3-Aminopropyl)-N-methylcarbamic acid tert-butyl ester|CS-B0431

Structure of 150349-36-3

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General Information

  • CAS No. 150349-36-3
  • Cat. No. CS-B0431
  • Purity ≥97%
  • MDL No. MFCD01631189
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₂₀N₂O₂
  • Molecular Weight 188.27
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)N(C)CCCN

Description

N-(3-Aminopropyl)-N-methylcarbamic acid tert-butyl ester features a protected amine handle ideal for downstream functionalization. The tert-butyl carbamate group ensures stability during synthesis and storage, while the primary amine enables efficient coupling reactions. This reagent integrates seamlessly into peptide extensions, dendrimer assembly, and bioconjugation workflows under standard conditions.

Application

N-(3-Aminopropyl)-N-methylcarbamic acid tert-butyl ester serves as a versatile bifunctional building block in synthetic organic chemistry, enabling efficient access to nitrogen-containing scaffolds. The tertiary amine and carbamate functionalities offer orthogonal reactivity, facilitating selective derivatization and protection strategies. Its bench-stable nature and compatibility with common coupling conditions make it well-suited for peptide conjugation, fragment-based drug discovery, and the construction of heterocyclic intermediates.

Synthesis

  • Route1

    References

    • TEMPERO PHARMACEUTICALS, INC.; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; BALOGLU, Erkan Patent: WO2013/6408 A1, 2013 ; Location in patent: Page/Page column 40 ;
  • Route2
    • null|null
      1198081-75-2
    • ~84%
    • In-stock
      N-(3-Aminopropyl)-N-methylcarbamic acid tert-butyl ester|CS-B0431
      150349-36-3

    References

    • Li, Hongbo; Hao, Meng-An; Wang, Liping; Liang, Wu; Chen, Kai Organic Preparations and Procedures International, 2009 , vol. 41, # 4 p. 301 - 307
  • Route3

    References

    • Choi, Doo Li; Jang, Sun Jeong; Cho, Sehyeon; Choi, Hye-Eun; Rim, Hong-Kun; Lee, Kyung-Tae; Lee, Jae Yeol Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 6 p. 1565 - 1570

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   55.56
  • LogP   1.2021
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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