Thalidomide-5,6-F

Name: Thalidomide-5,6-F
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1496997-41-1
Cat. No. CS-0142929
Purity≥98%
MDL No.MFCD32853274

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 1496997-41-1

Size

Price

Quantity

* Please select Quantity before adding items.

Description

Thalidomide-5,6-F exhibits enhanced metabolic stability due to fluorination at the 5,6-positions, which modulates electron density across the phthalimide ring. This substitution improves resistance to oxidative degradation while preserving the compound’s ability to engage target proteins involved in angiogenesis and inflammation. The fluorinated derivative offers a robust platform for probing structure-activity relationships in immunomodulatory drug development.

Application

Thalidomide-5,6-F serves as a fluorinated analog of thalidomide, enabling targeted exploration of structure-activity relationships in immunomodulatory and anti-angiogenic scaffolds. The 5,6-difluoro substitution enhances metabolic stability and modulates electronic properties, facilitating improved functional group tolerance in downstream conjugation reactions. Its bench-stable crystalline form simplifies handling and purification, making it suitable for use in medicinal chemistry campaigns requiring precise stereochemical control and predictable reactivity profiles.

General Information

CAS No. 1496997-41-1
Cat. No. CS-0142929
Purity ≥98%
MDL No. MFCD32853274
Storage 4°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₈F₂N₂O₄
Molecular Weight 294.21
Synonym(s) None
SMILES O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=C(F)C(F)=C3)=O

Computational Chemistry Data

TPSA 83.55
LogP 0.311
H_Acceptors 6
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic heterocycle compounds Other aromatic heterocycles compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Life Science PROTAC Ligands for E3 Ligase

General Reagents Organic General Reagents

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

Key Words

Thalidomide-5,6-F sigmaThalidomide-5,6-F manufacturerThalidomide-5,6-F priceThalidomide-5,6-F structureThalidomide-5,6-F SDSbuy Thalidomide-5,6-FThalidomide-5,6-F supplierThalidomide-5,6-F usesThalidomide-5,6-F molecular weightprice of Thalidomide-5,6-FThalidomide-5,6-F chemical name formula of Thalidomide-5,6-F

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

Thalidomide-5,6-F

CAS No. 1496997-41-1

Recommended Products