3,5-Difluorobenzamidine hydrochloride

Name: 3,5-Difluorobenzamidine hydrochloride
Brand: ChemScene
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CAS No. 144797-68-2
Cat. No. CS-0157681
Purity≥97%
MDL No.MFCD04114449

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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3,5-Difluorobenzamidine hydrochloride|CS-0157681

Structure of 144797-68-2

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General Information

CAS No. 144797-68-2
Cat. No. CS-0157681
Purity ≥97%
MDL No. MFCD04114449
Storage Store at room temperature, keep dry and cool
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₇ClF₂N₂
Molecular Weight 192.59
Synonym(s) benzenecarboximidamide, 3,5-difluoro- HYDROCHLORIDE
SMILES FC1=CC(F)=CC(C(N)=N)=C1.Cl

Description

3,5-Difluorobenzamidine hydrochloride delivers a potent amidine functionality flanked by two electron-withdrawing fluorine atoms, enhancing electrophilicity at the imine carbon. This bench-stable salt features high solubility in polar solvents, enabling straightforward incorporation into synthetic workflows for medicinal chemistry and catalytic applications.

Application

3,5-Difluorobenzamidine hydrochloride serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted benzimidazoles and related heterocycles via cyclization reactions. The difluoro substitution pattern enhances metabolic stability and modulates electronic properties, while the amidine functionality provides high reactivity in coupling processes. Its crystalline solid form ensures excellent bench stability and ease of handling, facilitating purification and scale-up in API synthesis workflows.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

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Computational Chemistry Data

TPSA 49.87
LogP 1.67067
H_Acceptors 1
H_Donors 2
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Amidine

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

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3,5-Difluorobenzamidine hydrochloride

CAS No. 144797-68-2

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