3-Fluorobenzene-1-carboximidamide hydrochloride

Name: 3-Fluorobenzene-1-carboximidamide hydrochloride
Brand: ChemScene
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CAS No. 75207-72-6
Cat. No. CS-0122237
Purity≥98%
MDL No.MFCD04114433

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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3-Fluorobenzene-1-carboximidamide hydrochloride|CS-0122237

Structure of 75207-72-6

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General Information

CAS No. 75207-72-6
Cat. No. CS-0122237
Purity ≥98%
MDL No. MFCD04114433
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₈ClFN₂
Molecular Weight 174.60
Synonym(s) 3-Fluorobenzamidine hydrochloride
SMILES N=C(C1=CC=CC(F)=C1)N.[H]Cl

Description

3-Fluorobenzene-1-carboximidamide hydrochloride features a fluorinated aromatic ring paired with a reactive imidamide functional group, enabling direct incorporation into bioactive scaffolds. This bench-stable salt form enhances solubility and handling in synthetic workflows, supporting efficient derivatization for medicinal chemistry applications.

Application

3-Fluorobenzene-1-carboximidamide hydrochloride serves as a versatile building block for heterocyclic synthesis, particularly in the construction of imidazole and triazole scaffolds. Its fluorinated aromatic core enhances metabolic stability and modulates electronic properties, while the imidamide functionality enables facile derivatization via condensation and cyclization reactions. The hydrochloride salt form ensures excellent bench stability and ease of handling, facilitating purification and integration into medicinal chemistry workflows.

Synthesis

Route1
- 133118-49-7
- ~%
- In-stock
  
  75207-72-6
References
- Journal of Medicinal Chemistry, , vol. 33, # 4 p. 1230 - 1241
Route2
- 403-54-3
- ~%
- In-stock
  
  75207-72-6
References
- Journal of Chemical Research, Miniprint, , # 9 p. 2963 - 2975

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 49.87
LogP 1.53157
H_Acceptors 1
H_Donors 2
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Amidine

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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3-Fluorobenzene-1-carboximidamide hydrochloride

CAS No. 75207-72-6

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