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CS-W001157 4
Total: USD 88.00

4-(Methylsulfonyl)piperidine

  • CAS No. 290328-55-1

  • Cat. No. CS-W005279
  • Molecule weight163.24
  • Purity≥95%
  • MDL No.MFCD11043260

*For research and further manufacturing use only, not for direct human use.

4-(Methylsulfonyl)piperidine|CS-W005279

Structure of 290328-55-1

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General Information

  • CAS No. 290328-55-1
  • Cat. No. CS-W005279
  • Purity ≥95%
  • MDL No. MFCD11043260
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₃NO₂S
  • Molecular Weight 163.24
  • Synonym(s) 4-Methanesulfonyl-piperidine
  • SMILES CS(=O)(=O)C1CCNCC1

Description

4-(Methylsulfonyl)piperidine is a bench-stable, electron-deficient piperidine derivative featuring a polar methylsulfonyl group at the 4-position. This functionalization enhances solubility and metabolic stability, enabling its use in medicinal chemistry scaffolds. The molecule integrates readily into bioactive compounds requiring controlled polarity and improved pharmacokinetic profiles.

Application

4-(Methylsulfonyl)piperidine serves as a versatile building block in medicinal chemistry, offering enhanced solubility and metabolic stability due to the polar methylsulfonyl group. It functions as a bioisostere for amine and hydroxyl groups, enabling improved pharmacokinetic profiles. The compound exhibits bench stability, tolerates a range of reaction conditions, and facilitates efficient incorporation into diverse heterocyclic scaffolds and API candidates through standard functionalization protocols.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.17
  • LogP   -0.217
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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