N-Fmoc-5,5,5-trifluoro-L-norvaline

Name: N-Fmoc-5,5,5-trifluoro-L-norvaline
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 144207-41-0
Cat. No. CS-0111668
Purity≥95%
MDL No.MFCD31580021

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Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

N-Fmoc-5,5,5-trifluoro-L-norvaline|CS-0111668

Structure of 144207-41-0

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General Information

CAS No. 144207-41-0
Cat. No. CS-0111668
Purity ≥95%
MDL No. MFCD31580021
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₀H₁₈F₃NO₄
Molecular Weight 393.36
Synonym(s) None
SMILES O=C(O)[C@H](CCC(F)(F)F)NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O

Description

N-Fmoc-5,5,5-trifluoro-L-norvaline features a trifluoromethyl-substituted aliphatic side chain that enhances metabolic stability and lipophilicity. This fluorinated amino acid integrates readily into peptide sequences under standard coupling conditions, offering improved membrane permeability and resistance to enzymatic degradation in bioactive peptide design.

Application

N-Fmoc-5,5,5-trifluoro-L-norvaline serves as a valuable building block in peptide synthesis, offering enhanced solubility and stability due to the Fmoc protecting group. The trifluoromethyl moiety imparts strong electron-withdrawing character, facilitating controlled activation and coupling reactions. Its functional group tolerance enables incorporation into complex peptide architectures, including those requiring hydrophobic or fluorinated side chains, making it ideal for medicinal chemistry campaigns targeting bioactive peptides.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 75.63
LogP 4.3208
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 6

Other Classifications

Life Science Amino Acids and their Derivatives Alanine and derivatives

Building Blocks Functional Group Fmoc

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

Key Words

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N-Fmoc-5,5,5-trifluoro-L-norvaline

CAS No. 144207-41-0

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