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Fmoc-β-D-HoTyr(tBu)-OH

  • CAS No. 1233495-02-7

  • Cat. No. CS-0187432
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Fmoc-β-D-HoTyr(tBu)-OH|CS-0187432

Structure of 1233495-02-7

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General Information

  • CAS No. 1233495-02-7
  • Cat. No. CS-0187432
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₉H₃₁NO₅
  • Molecular Weight 473.56
  • Synonym(s) FMoc-D-β-Hotyr(OtBu)-OH
  • SMILES CC(C)(OC1=CC=C(C[C@@H](NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O)CC(O)=O)C=C1)C

Description

Fmoc-β-D-HoTyr(tBu)-OH is a stereochemically defined amino acid derivative featuring a β-hydroxytyrosine scaffold with a tert-butyl protected phenolic hydroxyl. This bench-stable building block integrates readily into peptide chains, enabling the introduction of a polar, hydrogen-bonding moiety at defined positions within synthetic sequences.

Application

Fmoc-β-D-HoTyr(tBu)-OH serves as a valuable building block for the synthesis of peptide conjugates and peptidomimetics, enabling site-specific incorporation of β-hydroxytyrosine derivatives. The Fmoc group provides orthogonal protection for amine functionality, while the tert-butyl ether ensures stability during standard solid-phase peptide synthesis. Its D-stereoisomer configuration offers enhanced metabolic resistance, and the β-hydroxyl group facilitates downstream functionalization or hydrogen bonding in bioactive scaffolds.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   84.86
  • LogP   5.7884
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   8

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