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CS-W001157 4
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4-Bromo-2-fluoro-6-hydroxybenzaldehyde

  • CAS No. 1427438-90-1

  • Cat. No. CS-W022094
  • Purity≥96%
  • MDL No.MFCD23705560

*For research and further manufacturing use only, not for direct human use.

4-Bromo-2-fluoro-6-hydroxybenzaldehyde|CS-W022094

Structure of 1427438-90-1

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General Information

  • CAS No. 1427438-90-1
  • Cat. No. CS-W022094
  • Purity ≥96%
  • MDL No. MFCD23705560
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄BrFO₂
  • Molecular Weight 219.01
  • Synonym(s) 4-bromo-2-fluoro-6-hydroxybenzladehyde
  • SMILES O=CC1=C(O)C=C(Br)C=C1F

Description

4-Bromo-2-fluoro-6-hydroxybenzaldehyde features a trifunctional aromatic core with bromine, fluorine, and hydroxyl groups positioned ortho and para to the aldehyde. This electron-deficient scaffold enables direct coupling in cross-coupling reactions and serves as a building block for bioactive molecules and functional materials under standard conditions.

Application

4-Bromo-2-fluoro-6-hydroxybenzaldehyde serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the phenolic hydroxyl and aldehyde sites. Its ortho-halo substitution pattern facilitates palladium-catalyzed coupling reactions, while the fluorine atom enhances metabolic stability and modulates electronic properties. The compound exhibits bench stability and compatibility with standard protecting group strategies, supporting efficient synthesis of complex heterocyclic scaffolds and API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.1063
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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