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Tetrazine-Amine (monohydrochloride)

  • CAS No. 1416711-59-5

  • Cat. No. CS-0133664
  • Purity≥98%
  • MDL No.MFCD23097050

*For research and further manufacturing use only, not for direct human use.

Tetrazine-Amine (monohydrochloride)|CS-0133664

Structure of 1416711-59-5

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General Information

  • CAS No. 1416711-59-5
  • Cat. No. CS-0133664
  • Purity ≥98%
  • MDL No. MFCD23097050
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀ClN₅
  • Molecular Weight 223.67
  • Synonym(s) (4-(1,2,4,5-Tetrazin-3-yl)phenyl)methanamine (monohydrochloride); Tetrazine-NH2 (monohydrochloride)
  • SMILES NCC1=CC=C(C2=NN=CN=N2)C=C1.Cl

Description

Tetrazine-Amine (monohydrochloride) features a reactive tetrazine ring paired with a primary amine functionality, enabling efficient bioconjugation via inverse electron-demand Diels-Alder reactions. This bench-stable derivative combines high reactivity with ease of handling, facilitating rapid labeling under physiological conditions. The monohydrochloride salt enhances solubility and stability in aqueous systems.

Application

Tetrazine-Amine (monohydrochloride) serves as a reliable bifunctional building block for bioorthogonal conjugation, enabling rapid and selective ligation under physiological conditions. Its tetrazine moiety reacts efficiently with trans-cyclooctene (TCO) derivatives via inverse electron-demand Diels-Alder (IEDDA) cycloaddition, while the amine functionality facilitates conjugation to carboxylated biomolecules or solid supports. The monohydrochloride salt enhances solubility and stability in aqueous buffers, supporting straightforward handling and purification in peptide, antibody, and probe synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   77.58
  • LogP   0.8141
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   2

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