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CS-W001157 4
Total: USD 88.00

NH2-PEG5-C2-NH-Boc

  • CAS No. 189209-27-6

  • Cat. No. CS-0040961
  • Purity≥95%
  • MDL No.MFCD22056313

*For research and further manufacturing use only, not for direct human use.

NH2-PEG5-C2-NH-Boc|CS-0040961

Structure of 189209-27-6

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General Information

  • CAS No. 189209-27-6
  • Cat. No. CS-0040961
  • Purity ≥95%
  • MDL No. MFCD22056313
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₇H₃₆N₂O₇
  • Molecular Weight 380.48
  • Synonym(s) PROTAC Linker 17
  • SMILES O=C(OC(C)(C)C)NCCOCCOCCOCCOCCOCCN

Description

NH2-PEG5-C2-NH-Boc features a five-ethylene glycol unit chain flanked by an amine and a Boc-protected amine, offering enhanced solubility and stability. This bifunctional linker enables efficient conjugation in peptide synthesis and biomolecule labeling, with the protected amine allowing controlled deprotection under mild acidic conditions.

Application

NH2-PEG5-C2-NH-Boc serves as a versatile bifunctional linker for peptide and protein conjugation, combining the solubility and biocompatibility of PEG with orthogonal functional handles. The primary amine enables coupling to carboxyl-containing biomolecules, while the Boc-protected amine facilitates sequential modification or controlled deprotection under mild acidic conditions. Its well-defined structure supports reproducible synthesis in therapeutic development and diagnostic probe design.

Synthesis

  • Route1
    • Boc-NH-PEG5-azide|CS-0115526
      911209-07-9
    • ~99%
    • In-stock
      NH2-PEG5-C2-NH-Boc|CS-0040961
      189209-27-6

    References

    • Gerard, Estelle; Meulle, Aline; Feron, Olivier; Marchand-Brynaert, Jacqueline Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 586 - 590
  • Route2

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 1 p. 586 - 590
  • Route3

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 1 p. 586 - 590

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   110.5
  • LogP   0.5528
  • H_Acceptors   8
  • H_Donors   2
  • Rotatable_Bonds   17

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