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Structure of 1411774-27-0
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(R)-3-Fluoropyrrolidine-1-sulfonyl chloride features a chiral sulfonyl chloride moiety that enables selective derivatization in asymmetric synthesis. The fluorinated pyrrolidine scaffold imparts enhanced metabolic stability and modulates electronic properties, making it valuable for medicinal chemistry applications requiring precise stereocontrol and improved pharmacokinetic profiles.
(R)-3-Fluoropyrrolidine-1-sulfonyl chloride serves as a versatile chiral building block for the synthesis of fluorinated sulfonamide-containing compounds. Its sulfonyl chloride functionality enables efficient coupling with amines and alcohols under mild conditions, facilitating the construction of bioactive scaffolds. The chiral pyrrolidine core provides stereochemical control in medicinal chemistry applications, while the fluorine substituent enhances metabolic stability and membrane permeability. Bench-stable and readily purified by distillation or recrystallization, it functions as a key intermediate in the development of targeted therapeutics and functionalized heterocycles.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H314
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Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501
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Lot numbers can be found on the outside label of a product: