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CS-W001157 4
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2-Aminomethyl-4-boc-morpholine

  • CAS No. 140645-53-0

  • Cat. No. CS-W003285
  • Purity≥95%
  • MDL No.MFCD06410633

*For research and further manufacturing use only, not for direct human use.

2-Aminomethyl-4-boc-morpholine|CS-W003285

Structure of 140645-53-0

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General Information

  • CAS No. 140645-53-0
  • Cat. No. CS-W003285
  • Purity ≥95%
  • MDL No. MFCD06410633
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₂₀N₂O₃
  • Molecular Weight 216.28
  • Synonym(s) Tert-butyl 2-(aminomethyl)morpholine-4-carboxylate
  • SMILES NCC1OCCN(C1)C(=O)OC(C)(C)C

Description

2-Aminomethyl-4-Boc-morpholine delivers a protected amine handle for modular synthesis, enabling direct coupling without side-reaction interference. The Boc group ensures stability during handling and purification, while the morpholine ring provides solubility and structural rigidity. This scaffold integrates seamlessly into diverse molecular architectures.

Application

2-Aminomethyl-4-Boc-morpholine serves as a versatile bifunctional building block in medicinal chemistry, enabling efficient access to morpholine-based scaffolds. The Boc group provides stable protection of the amine under standard conditions, while the primary amine facilitates facile coupling reactions and derivatization. Its compatibility with common synthetic transformations and ease of deprotection make it a practical choice for constructing bioactive heterocycles and peptide conjugates.

Synthesis

  • Route1
    • tert-Butyl 2-((1,3-dioxoisoindolin-2-yl)methyl)morpholine-4-carboxylate|CS-0020569
      876147-52-3
    • ~83%
    • In-stock
      2-Aminomethyl-4-boc-morpholine|CS-W003285
      140645-53-0

    References

    • KYORIN PHARMACEUTICAL CO., LTD. Patent: EP1780210 A1, 2007 ; Location in patent: Page/Page column 57 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   64.79
  • LogP   0.581
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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