(4-Methylmorpholin-2-yl)methanamine

Name: (4-Methylmorpholin-2-yl)methanamine
Brand: ChemScene
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CAS No. 141814-57-5
Cat. No. CS-W005495
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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(4-Methylmorpholin-2-yl)methanamine|CS-W005495

Structure of 141814-57-5

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General Information

CAS No. 141814-57-5
Cat. No. CS-W005495
Purity ≥98%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₁₄N₂O
Molecular Weight 130.19
Synonym(s) 4-Methyl-2-aminomethylmorpholine
SMILES NCC1CN(C)CCO1

Description

This amine features a 4-methylmorpholine ring linked to a methanamine group, delivering enhanced solubility and nucleophilicity. The electron-rich heterocycle enables efficient coupling in synthetic transformations, while the primary amine facilitates straightforward derivatization. Stable under standard conditions, this reagent integrates seamlessly into medicinal chemistry workflows requiring polar, basic nitrogen functionalities.

Application

(4-Methylmorpholin-2-yl)methanamine serves as a versatile bifunctional building block in medicinal chemistry, enabling efficient access to complex nitrogen-containing scaffolds. Its morpholine core provides excellent solubility and metabolic stability, while the primary amine facilitates conjugation reactions and derivatization. The molecule exhibits robust bench stability and compatibility with standard coupling protocols, making it well-suited for modular synthesis of drug candidates and functionalized intermediates.

Synthesis

Route1
- 791006-53-6
- ~%
- In-stock
  
  141814-57-5
References
- Chemical and Pharmaceutical Bulletin, , vol. 40, # 3 p. 652 - 660

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 38.49
LogP -0.7243
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Morpholine compounds

Key Words

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(4-Methylmorpholin-2-yl)methanamine

CAS No. 141814-57-5

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