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CS-W001157 4
Total: USD 88.00

(S)-N-Boc-2-aminomethylmorpholine

  • CAS No. 879403-42-6

  • Cat. No. CS-M3378
  • Purity≥97%
  • MDL No.MFCD11707017

*For research and further manufacturing use only, not for direct human use.

(S)-N-Boc-2-aminomethylmorpholine|CS-M3378

Structure of 879403-42-6

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General Information

  • CAS No. 879403-42-6
  • Cat. No. CS-M3378
  • Purity ≥97%
  • MDL No. MFCD11707017
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₂₀N₂O₃
  • Molecular Weight 216.28
  • Synonym(s) tert-Butyl-(2S)-2-(aminomethyl)morpholin-4-carboxylat
  • SMILES NC[C@@H]1OCCN(C(OC(C)(C)C)=O)C1

Description

(S)-N-Boc-2-aminomethylmorpholine features a chiral morpholine scaffold with a stable Boc-protected amine, enabling direct incorporation into peptide and small-molecule syntheses. This bench-stable derivative facilitates efficient coupling reactions under standard conditions, offering precise stereochemical control in complex molecular architectures.

Application

(S)-N-Boc-2-aminomethylmorpholine serves as a versatile chiral building block for the synthesis of bioactive molecules, enabling efficient access to morpholine-containing scaffolds. Its Boc-protected amine and pendant morpholine ring provide orthogonal reactivity, facilitating selective functionalization in multi-step sequences. The compound exhibits excellent bench stability, simplifies purification, and functions reliably in standard coupling and reduction protocols common in medicinal chemistry workflows.

Synthesis

  • Route1
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      1308849-91-3
    • ~%
    • In-stock
      (S)-N-Boc-2-aminomethylmorpholine|CS-M3378
      879403-42-6

    References

    • WO2011/62550 A1, ; Page/Page column 26-27 ; WO 2011/062550 A1
  • Route2
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      921211-91-8
    • ~%
    • In-stock
      (S)-N-Boc-2-aminomethylmorpholine|CS-M3378
      879403-42-6

    References

    • Journal of Medicinal Chemistry, , vol. 52, # 15 p. 4810 - 4819
  • Route3

    References

    • WO2011/62550 A1, ; WO 2011/062550 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   64.79
  • LogP   0.581
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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