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Propargyl-PEG5-NHS ester

  • CAS No. 1393330-40-9

  • Cat. No. CS-0107584
  • Purity≥95%
  • MDL No.MFCD22574798

*For research and further manufacturing use only, not for direct human use.

Propargyl-PEG5-NHS ester|CS-0107584

Structure of 1393330-40-9

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General Information

  • CAS No. 1393330-40-9
  • Cat. No. CS-0107584
  • Purity ≥95%
  • MDL No. MFCD22574798
  • Storage -20°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₈H₂₇NO₉
  • Molecular Weight 401.41
  • Synonym(s) None
  • SMILES C#CCOCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O

Description

Propargyl-PEG5-NHS ester enables efficient conjugation of biomolecules via bioorthogonal click chemistry. The terminal alkyne group facilitates copper-catalyzed azide-alkyne cycloaddition, while the PEG5 spacer provides solubility and reduced non-specific binding. This reagent is stable under physiological conditions and ideal for labeling proteins, antibodies, and nucleic acids.

Application

Propargyl-PEG5-NHS ester serves as a versatile bifunctional linker for conjugating biomolecules, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) via its terminal alkyne group. The PEG5 spacer provides enhanced solubility and reduced non-specific binding, while the NHS ester readily reacts with primary amines under physiological conditions. This reagent facilitates site-specific labeling and bioconjugation in peptide, protein, and oligonucleotide modifications, offering robust stability and straightforward purification.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   109.83
  • LogP   -0.3001
  • H_Acceptors   9
  • H_Donors   0
  • Rotatable_Bonds   17

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