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CS-W001157 4
Total: USD 88.00

Propargyl-PEG4-NHS ester

  • CAS No. 1428629-70-2

  • Cat. No. CS-0105066
  • Molecule weight357.36
  • Purity≥95%
  • MDL No.MFCD22380743

*For research and further manufacturing use only, not for direct human use.

Propargyl-PEG4-NHS ester|CS-0105066

Structure of 1428629-70-2

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General Information

  • CAS No. 1428629-70-2
  • Cat. No. CS-0105066
  • Purity ≥95%
  • MDL No. MFCD22380743
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₂₃NO₈
  • Molecular Weight 357.36
  • Synonym(s) None
  • SMILES C#CCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O

Description

Propargyl-PEG4-NHS ester enables efficient conjugation of biomolecules under physiological conditions. This water-soluble linker features a terminal alkyne for click chemistry and a reactive NHS ester for amine coupling, combining orthogonal functionality with excellent stability in aqueous environments.

Application

Propargyl-PEG4-NHS ester serves as a versatile, water-soluble linker for bioconjugation, enabling efficient coupling to primary amines under mild conditions. The propargyl group provides a reliable handle for copper-catalyzed azide-alkyne cycloaddition (CuAAC), while the PEG4 spacer enhances solubility and reduces non-specific binding. This reagent exhibits excellent bench stability and facilitates clean purification, making it ideal for constructing functionalized probes, antibody-drug conjugates, and polymer-based delivery systems.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   100.6
  • LogP   -0.3167
  • H_Acceptors   8
  • H_Donors   0
  • Rotatable_Bonds   14

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