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Total: USD 88.00

Propargyl-PEG2-NHS ester

  • CAS No. 2512228-06-5

  • Cat. No. CS-0167730
  • Molecule weight269.25
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Propargyl-PEG2-NHS ester|CS-0167730

Structure of 2512228-06-5

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General Information

  • CAS No. 2512228-06-5
  • Cat. No. CS-0167730
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₅NO₆
  • Molecular Weight 269.25
  • Synonym(s) None
  • SMILES O=C(CCOCCOCC#C)ON1C(CCC1=O)=O

Description

Propargyl-PEG2-NHS ester enables site-specific conjugation in aqueous media, combining a reactive NHS group with a terminal alkyne for bioorthogonal labeling. This bifunctional linker features a short PEG spacer that enhances solubility and reduces steric hindrance, facilitating efficient coupling to primary amines on proteins, antibodies, or peptides while preserving functional integrity.

Application

Propargyl-PEG2-NHS ester serves as a versatile bifunctional linker for conjugation chemistry, enabling efficient coupling of biomolecules to surfaces or solid supports via its reactive NHS ester group. The propargyl moiety provides a bioorthogonal handle for copper-catalyzed azide-alkyne cycloaddition (CuAAC), facilitating site-specific labeling and assembly of functionalized constructs. Its PEG2 spacer enhances solubility and reduces non-specific binding, while the reagent exhibits excellent bench stability and ease of purification—ideal for applications in probe synthesis, protein modification, and materials science.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   82.14
  • LogP   -0.3499
  • H_Acceptors   6
  • H_Donors   0
  • Rotatable_Bonds   8

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